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PLA2G5 (phospholipase A2 group V)

Identity

Alias_namesphospholipase A2, group V
Other aliasFRFB
GV-PLA2
PLA2-10
hVPLA(2)
HGNC (Hugo) PLA2G5
LocusID (NCBI) 5322
Atlas_Id 41734
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 20070208 and ends at 20091901 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ECE1 (1p36.12) / PLA2G5 (1p36.13)ECE1 1p36.12 / PLA2G5 1p36.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ECE1/PLA2G5 (1p36)

External links

Nomenclature
HGNC (Hugo)PLA2G5   9038
Cards
Entrez_Gene (NCBI)PLA2G5  5322  phospholipase A2 group V
AliasesFRFB; GV-PLA2; PLA2-10; hVPLA(2)
GeneCards (Weizmann)PLA2G5
Ensembl hg19 (Hinxton)ENSG00000127472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127472 [Gene_View]  ENSG00000127472 [Sequence]  chr1:20070208-20091901 [Contig_View]  PLA2G5 [Vega]
ICGC DataPortalENSG00000127472
TCGA cBioPortalPLA2G5
AceView (NCBI)PLA2G5
Genatlas (Paris)PLA2G5
WikiGenes5322
SOURCE (Princeton)PLA2G5
Genetics Home Reference (NIH)PLA2G5
Genomic and cartography
GoldenPath hg38 (UCSC)PLA2G5  -     chr1:20070208-20091901 +  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PLA2G5  -     1p36.13   [Description]    (hg19-Feb_2009)
GoldenPathPLA2G5 - 1p36.13 [CytoView hg19]  PLA2G5 - 1p36.13 [CytoView hg38]
ImmunoBaseENSG00000127472
Mapping of homologs : NCBIPLA2G5 [Mapview hg19]  PLA2G5 [Mapview hg38]
OMIM228980   601192   
Gene and transcription
Genbank (Entrez)AK097693 AV709457 BC036792 BM684907 BM705479
RefSeq transcript (Entrez)NM_000929
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PLA2G5
Cluster EST : UnigeneHs.319438 [ NCBI ]
CGAP (NCI)Hs.319438
Alternative Splicing GalleryENSG00000127472
Gene ExpressionPLA2G5 [ NCBI-GEO ]   PLA2G5 [ EBI - ARRAY_EXPRESS ]   PLA2G5 [ SEEK ]   PLA2G5 [ MEM ]
Gene Expression Viewer (FireBrowse)PLA2G5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5322
GTEX Portal (Tissue expression)PLA2G5
Human Protein AtlasENSG00000127472-PLA2G5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP39877   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP39877  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP39877
Splice isoforms : SwissVarP39877
Catalytic activity : Enzyme3.1.1.4 [ Enzyme-Expasy ]   3.1.1.43.1.1.4 [ IntEnz-EBI ]   3.1.1.4 [ BRENDA ]   3.1.1.4 [ KEGG ]   
PhosPhoSitePlusP39877
Domaine pattern : Prosite (Expaxy)PA2_ASP (PS00119)    PA2_HIS (PS00118)   
Domains : Interpro (EBI)PLipase_A2    PLipase_A2_Asp_AS    PLipase_A2_dom    PLipase_A2_dom_sf    PLipase_A2_His_AS   
Domain families : Pfam (Sanger)Phospholip_A2_1 (PF00068)   
Domain families : Pfam (NCBI)pfam00068   
Domain families : Smart (EMBL)PA2c (SM00085)  
Conserved Domain (NCBI)PLA2G5
DMDM Disease mutations5322
Blocks (Seattle)PLA2G5
PDB (RSDB)2GHN   
PDB Europe2GHN   
PDB (PDBSum)2GHN   
PDB (IMB)2GHN   
Structural Biology KnowledgeBase2GHN   
SCOP (Structural Classification of Proteins)2GHN   
CATH (Classification of proteins structures)2GHN   
SuperfamilyP39877
Human Protein Atlas [tissue]ENSG00000127472-PLA2G5 [tissue]
Peptide AtlasP39877
HPRD03117
IPIIPI00026664   
Protein Interaction databases
DIP (DOE-UCLA)P39877
IntAct (EBI)P39877
FunCoupENSG00000127472
BioGRIDPLA2G5
STRING (EMBL)PLA2G5
ZODIACPLA2G5
Ontologies - Pathways
QuickGOP39877
Ontology : AmiGOphospholipase A2 activity  calcium ion binding  phospholipid binding  extracellular region  Golgi apparatus  plasma membrane  phospholipid metabolic process  phosphatidic acid biosynthetic process  platelet activating factor biosynthetic process  heparin binding  positive regulation of phospholipase activity  lipid catabolic process  leukotriene biosynthetic process  response to cytokine  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  calcium-dependent phospholipase A2 activity  perinuclear region of cytoplasm  arachidonic acid secretion  response to cAMP  positive regulation of ERK1 and ERK2 cascade  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Ontology : EGO-EBIphospholipase A2 activity  calcium ion binding  phospholipid binding  extracellular region  Golgi apparatus  plasma membrane  phospholipid metabolic process  phosphatidic acid biosynthetic process  platelet activating factor biosynthetic process  heparin binding  positive regulation of phospholipase activity  lipid catabolic process  leukotriene biosynthetic process  response to cytokine  phosphatidylglycerol acyl-chain remodeling  phosphatidylinositol acyl-chain remodeling  phosphatidylserine acyl-chain remodeling  phosphatidylcholine acyl-chain remodeling  phosphatidylethanolamine acyl-chain remodeling  calcium-dependent phospholipase A2 activity  perinuclear region of cytoplasm  arachidonic acid secretion  response to cAMP  positive regulation of ERK1 and ERK2 cascade  phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)  phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)  
Pathways : KEGGGlycerophospholipid metabolism    Ether lipid metabolism    Arachidonic acid metabolism    Linoleic acid metabolism    alpha-Linolenic acid metabolism    Ras signaling pathway    Vascular smooth muscle contraction    Pancreatic secretion    Fat digestion and absorption   
NDEx NetworkPLA2G5
Atlas of Cancer Signalling NetworkPLA2G5
Wikipedia pathwaysPLA2G5
Orthology - Evolution
OrthoDB5322
GeneTree (enSembl)ENSG00000127472
Phylogenetic Trees/Animal Genes : TreeFamPLA2G5
HOGENOMP39877
Homologs : HomoloGenePLA2G5
Homology/Alignments : Family Browser (UCSC)PLA2G5
Gene fusions - Rearrangements
Fusion : MitelmanECE1/PLA2G5 [1p36.12/1p36.13]  [t(1;1)(p36;p36)]  
Fusion PortalECE1 1p36.12 PLA2G5 1p36.13 SKCM
Fusion : QuiverPLA2G5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPLA2G5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PLA2G5
dbVarPLA2G5
ClinVarPLA2G5
1000_GenomesPLA2G5 
Exome Variant ServerPLA2G5
ExAC (Exome Aggregation Consortium)ENSG00000127472
GNOMAD BrowserENSG00000127472
Varsome BrowserPLA2G5
Genetic variants : HAPMAP5322
Genomic Variants (DGV)PLA2G5 [DGVbeta]
DECIPHERPLA2G5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPLA2G5 
Mutations
ICGC Data PortalPLA2G5 
TCGA Data PortalPLA2G5 
Broad Tumor PortalPLA2G5
OASIS PortalPLA2G5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPLA2G5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPLA2G5
Mutations and Diseases : HGMDPLA2G5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch PLA2G5
DgiDB (Drug Gene Interaction Database)PLA2G5
DoCM (Curated mutations)PLA2G5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PLA2G5 (select a term)
intoGenPLA2G5
Cancer3DPLA2G5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM228980    601192   
Orphanet22356   
DisGeNETPLA2G5
MedgenPLA2G5
Genetic Testing Registry PLA2G5
NextProtP39877 [Medical]
TSGene5322
GENETestsPLA2G5
Target ValidationPLA2G5
Huge Navigator PLA2G5 [HugePedia]
snp3D : Map Gene to Disease5322
BioCentury BCIQPLA2G5
ClinGenPLA2G5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5322
Chemical/Pharm GKB GenePA33366
Clinical trialPLA2G5
Miscellaneous
canSAR (ICR)PLA2G5 (select the gene name)
DataMed IndexPLA2G5
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePLA2G5
EVEXPLA2G5
GoPubMedPLA2G5
iHOPPLA2G5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:01:08 CET 2019
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