PLEKHA6 (pleckstrin homology domain containing A6)

2007-04-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
PEPP-3,PEPP3
FUSION GENES

Other Information

Locus ID:

NCBI: 22874
MIM: 607771
HGNC: 17053
Ensembl: ENSG00000143850

Variants:

dbSNP: 22874
ClinVar: 22874
TCGA: ENSG00000143850
COSMIC: PLEKHA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143850ENST00000272203Q9Y2H5
ENSG00000143850ENST00000414478Q5VTI5
ENSG00000143850ENST00000564627A0A1B0GW03
ENSG00000143850ENST00000637508A0A1B0GUN5

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
245765332014Pleckstrin homology domain containing 6 protein (PLEKHA6) polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients.3

Citation

Dessen P

PLEKHA6 (pleckstrin homology domain containing A6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47509/plekha6