PLEKHA8 (pleckstrin homology domain containing A8)

2007-04-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
FAPP2
FUSION GENES

Other Information

Locus ID:

NCBI: 84725
MIM: 608639
HGNC: 30037
Ensembl: ENSG00000106086

Variants:

dbSNP: 84725
ClinVar: 84725
TCGA: ENSG00000106086
COSMIC: PLEKHA8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106086ENST00000258679Q96JA3
ENSG00000106086ENST00000396257Q96JA3
ENSG00000106086ENST00000396259B5MDU3
ENSG00000106086ENST00000440706Q96JA3
ENSG00000106086ENST00000440706A0A2P1JJM6
ENSG00000106086ENST00000449726Q96JA3
ENSG00000106086ENST00000449726A0A2P1JJM6
ENSG00000106086ENST00000622102A0A087X1S6
ENSG00000106086ENST00000649443A0A3B3IST3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499

References

Pubmed IDYearTitleCitations
151078602004FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.200
176873302007Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.140
171168932006FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells.97
161032222005FAPP2 is involved in the transport of apical cargo in polarized MDCK cells.38
251227792014Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.30
199402492009Golgi protein FAPP2 tubulates membranes.27
222660152012Connecting vesicular transport with lipid synthesis: FAPP2.9
193417122009FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis.4
302061202018Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family.2
304084642019FAPP2 promotes tumor cell growth in human colon cancer through activation of Wnt signaling.2

Citation

Dessen P

PLEKHA8 (pleckstrin homology domain containing A8)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47128/plekha8