PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2)

2003-06-01  

Identity

HGNC
PLEKHG2
LOCATION
19q13.2
LOCUSID
64857
ALIAS
ARHGEF42,CLG,CTB-60E11.4,LDAMD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64857
MIM: 611893
HGNC: 29515
Ensembl: ENSG00000090924

Variants:

dbSNP: 64857
ClinVar: 64857
TCGA: ENSG00000090924
COSMIC: PLEKHG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090924ENST00000205135H7BXC7
ENSG00000090924ENST00000409797Q9H7P9
ENSG00000090924ENST00000425673Q9H7P9
ENSG00000090924ENST00000438123C9J7S4
ENSG00000090924ENST00000451354C9JVL3
ENSG00000090924ENST00000458508E7ESZ3
ENSG00000090924ENST00000594124M0R348
ENSG00000090924ENST00000594161M0R0V0
ENSG00000090924ENST00000595920M0R391
ENSG00000090924ENST00000596339M0QZT7
ENSG00000090924ENST00000596443M0QX05
ENSG00000090924ENST00000598238M0R3G5
ENSG00000090924ENST00000600210M0R3J0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
180458772008Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.26
240017682013PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.12
118397482002Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.6
199110112010Mutation of ARHGAP9 in patients with coronary spastic angina.5
230003412013Identification of a Rho family specific guanine nucleotide exchange factor, FLJ00018, as a novel actin-binding protein.5
245547032014Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells.5
243785322014PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway.4
277658162016Four-and-a-half LIM Domains 1 (FHL1) Protein Interacts with the Rho Guanine Nucleotide Exchange Factor PLEKHG2/FLJ00018 and Regulates Cell Morphogenesis.2
238115702013The importance of interaction with membrane lipids through the pleckstrin homology domain of the guanine nucleotide exchange factor for rho family small guanosine triphosphatase, FLJ00018.1
265730212016Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization.1

Citation

Dessen P

PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40101/plekhg2