PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6)

2009-08-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
MyoGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 55200
MIM: 611743
HGNC: 25562
Ensembl: ENSG00000008323

Variants:

dbSNP: 55200
ClinVar: 55200
TCGA: ENSG00000008323
COSMIC: PLEKHG6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008323ENST00000011684Q3KR16
ENSG00000008323ENST00000011684A0A2X0TW08
ENSG00000008323ENST00000304581Q3KR16
ENSG00000008323ENST00000396988Q3KR16
ENSG00000008323ENST00000396988A0A2X0TW08
ENSG00000008323ENST00000449001Q3KR16
ENSG00000008323ENST00000536531F5H731

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
178817352007Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.32
194211442009Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.30
186949342008Phosphorylation of MyoGEF on Thr-574 by Plk1 promotes MyoGEF localization to the central spindle.16
206342882010GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.10
244822372014Phosphorylation of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) at threonine 544 by aurora B kinase promotes the binding of polo-like kinase 1 to MyoGEF.4
293212502018Myosin II-interacting guanine nucleotide exchange factor promotes bleb retraction via stimulating cortex reassembly at the bleb membrane.3
305178612018A Primate-Specific Isoform of PLEKHG6 Regulates Neurogenesis and Neuronal Migration.3
253366412014Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.2

Citation

Dessen P

PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51012/plekhg6