PLK2 (polo like kinase 2)

2007-11-01  

Identity

HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
SNK,hPlk2,hSNK

Other Information

Locus ID:

NCBI: 10769
MIM: 607023
HGNC: 19699
Ensembl: ENSG00000145632

Variants:

dbSNP: 10769
ClinVar: 10769
TCGA: ENSG00000145632
COSMIC: PLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145632ENST00000274289Q9NYY3
ENSG00000145632ENST00000274289A0A024QZV1
ENSG00000145632ENST00000617412A0A087WUH9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370948472023Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.0
370948472023Polo-Like Kinase 2 Is Identified in Hypertrophy, Extracellular Matrix Accumulation, and Oxidative Stress of Mesangial Cells in Diabetic Nephropathy through p38-MAPK Signaling.0
352565382022Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.4
355793802022Combination of FOXD1 and Plk2: A novel biomarker for predicting unfavourable prognosis of colorectal cancer.4
352565382022Polo-like kinases as potential targets and PLK2 as a novel biomarker for the prognosis of human glioblastoma.4
355793802022Combination of FOXD1 and Plk2: A novel biomarker for predicting unfavourable prognosis of colorectal cancer.4
337996082021Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.7
340604152021Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.6
340802902021Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.8
344332922021Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.11
337996082021Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.7
340604152021Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.6
340802902021Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.8
344332922021Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.11
321921902020Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.39

Citation

Dessen P

PLK2 (polo like kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49829/plk2