PLK4 (polo like kinase 4)

2007-02-01  

Identity

HGNC
LOCATION
4q28.1
LOCUSID
ALIAS
MCCRP2,SAK,STK18

Other Information

Locus ID:

NCBI: 10733
MIM: 605031
HGNC: 11397
Ensembl: ENSG00000142731

Variants:

dbSNP: 10733
ClinVar: 10733
TCGA: ENSG00000142731
COSMIC: PLK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142731ENST00000270861O00444
ENSG00000142731ENST00000507249J3KR84
ENSG00000142731ENST00000508113H0YAL6
ENSG00000142731ENST00000513090O00444
ENSG00000142731ENST00000514379O00444
ENSG00000142731ENST00000515069J3KR82

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
FoxO signaling pathwayKEGGhsa04068
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162446682005The Polo kinase Plk4 functions in centriole duplication.311
176811312007Plk4-induced centriole biogenesis in human cells.279
163261022005SAK/PLK4 is required for centriole duplication and flagella development.224
210598502010Cep152 interacts with Plk4 and is required for centriole duplication.124
210598442010Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.119
205161512010Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation.89
253420352014Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.84
236410732013Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.81
209238222010Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.79
223496982012Cell-cycle-regulated expression of STIL controls centriole number in human cells.74

Citation

Dessen P

PLK4 (polo like kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43733/plk4