PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3)

2021-06-01  

Identity

HGNC
PLOD3
LOCATION
7q22.1
LOCUSID
8985
ALIAS
LH3

Other Information

Locus ID:

NCBI: 8985
MIM: 603066
HGNC: 9083
Ensembl: ENSG00000106397

Variants:

dbSNP: 8985
ClinVar: 8985
TCGA: ENSG00000106397
COSMIC: PLOD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106397ENST00000223127O60568
ENSG00000106397ENST00000414785C9JU11
ENSG00000106397ENST00000421736H7C2V1
ENSG00000106397ENST00000424135H7C2A8
ENSG00000106397ENST00000440925H7C0B8
ENSG00000106397ENST00000454310H7C2S8
ENSG00000106397ENST00000456079C9JIX5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Other types of O-glycan biosynthesisKEGGko00514
Lysine degradationKEGGhsa00310
Other types of O-glycan biosynthesisKEGGhsa00514
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188349682008A connective tissue disorder caused by mutations of the lysyl hydroxylase 3 gene.38
124756402002The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro.30
164472512006Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling.23
119561922002Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.21
258254952015Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation.20
182986582009The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability.16
214654732012Lysyl hydroxylase 3 is secreted from cells by two pathways.11
274352972016Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.11
272337932016Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.9
209557922011Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547.7

Citation

Dessen P

PLOD3 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58323/plod3