PLSCR4 (phospholipid scramblase 4)

2014-11-01  

Identity

HGNC
PLSCR4
LOCATION
3q24
LOCUSID
57088
ALIAS
TRA1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57088
MIM: 607612
HGNC: 16497
Ensembl: ENSG00000114698

Variants:

dbSNP: 57088
ClinVar: 57088
TCGA: ENSG00000114698
COSMIC: PLSCR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114698ENST00000354952Q9NRQ2
ENSG00000114698ENST00000383083E9PHR9
ENSG00000114698ENST00000433593Q9NRQ2
ENSG00000114698ENST00000446574Q9NRQ2
ENSG00000114698ENST00000460350C9J6E1
ENSG00000114698ENST00000460885C9JNW2
ENSG00000114698ENST00000476202C9J916
ENSG00000114698ENST00000481701C9J664
ENSG00000114698ENST00000493382Q9NRQ2
ENSG00000114698ENST00000498625C9J3P9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
216900872011A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1.28
193333782009The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane.19
195403102009Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell.6
314093842019DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.5
230896412012Biochemical and functional characterization of human phospholipid scramblase 4 (hPLSCR4).2
313225452019Long non-coding RNA LINC00641 suppresses non-small-cell lung cancer by sponging miR-424-5p to upregulate PLSCR4.2
273636672016Snail represses the expression of human phospholipid scramblase 4 gene.0

Citation

Dessen P

PLSCR4 (phospholipid scramblase 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72008/plscr4