PLXNA3 (plexin A3)

2012-01-01 Affiliation

Identity

HGNC

PLXNA3

LOCATION

Xq28

LOCUSID

55558

ALIAS

6.3,HSSEXGENE,PLXN3,PLXN4,XAP-6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55558
MIM: 300022
HGNC: 9101
Ensembl: ENSG00000130827

Variants:

dbSNP: 55558
ClinVar: 55558
TCGA: ENSG00000130827
COSMIC: PLXNA3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130827	ENST00000369682	P51805

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
CRMPs in Sema3A signaling	REACTOME	R-HSA-399956

References

Pubmed ID	Year	Title	Citations
19480842	2009	Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.	33
21925246	2011	Semaphorin-plexin signalling genes associated with human breast tumourigenesis.	5
25518740	2015	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	2
28536997	2017	PLXNA3 Variant rs5945430 is Associated with Severe Clinical Course in Male Multiple Sclerosis Patients.	0

Citation

Dessen P

PLXNA3 (plexin A3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52529/plxna3