PLXNA4 (plexin A4)

2011-12-01 Affiliation

Identity

HGNC

PLXNA4

LOCATION

7q32.3

LOCUSID

91584

ALIAS

FAYV2820,PLEXA4,PLXNA4A,PLXNA4B,PRO34003

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 91584
MIM: 604280
HGNC: 9102
Ensembl: ENSG00000221866

Variants:

dbSNP: 91584
ClinVar: 91584
TCGA: ENSG00000221866
COSMIC: PLXNA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000221866	ENST00000321063	Q9HCM2
ENSG00000221866	ENST00000321063	A0A024R7A6
ENSG00000221866	ENST00000359827	Q9HCM2
ENSG00000221866	ENST00000359827	A0A024R7A6
ENSG00000221866	ENST00000378539	Q9HCM2
ENSG00000221866	ENST00000423507	Q9HCM2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
CRMPs in Sema3A signaling	REACTOME	R-HSA-399956
Other semaphorin interactions	REACTOME	R-HSA-416700

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19401682	2010	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	52
21832283	2011	Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling.	34
25043464	2014	PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.	24
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
29898965	2018	B7-H4 Modulates Regulatory CD4⁺ T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex.	8
27378688	2016	Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.	5
24244438	2013	Rare variants in PLXNA4 and Parkinson's disease.	4
29661844	2018	Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilins.	4

Citation

Dessen P

PLXNA4 (plexin A4)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52503/plxna4