PLXNC1 (plexin C1)

2007-02-01  

Identity

HGNC
LOCATION
12q22
LOCUSID
ALIAS
CD232,PLXN-C1,VESPR
FUSION GENES

Other Information

Locus ID:

NCBI: 10154
MIM: 604259
HGNC: 9106
Ensembl: ENSG00000136040

Variants:

dbSNP: 10154
ClinVar: 10154
TCGA: ENSG00000136040
COSMIC: PLXNC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136040ENST00000258526O60486
ENSG00000136040ENST00000545312F5H3A2
ENSG00000136040ENST00000547057B4DHQ7
ENSG00000136040ENST00000549217F8W1K6
ENSG00000136040ENST00000550080F8W095
ENSG00000136040ENST00000551850F8VUW4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207275752010Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.57
189876702009Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progression.40
176715192008Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins.28
193188062009The semaphorin 7A receptor Plexin C1 is lost during melanoma metastasis.22
276097732016Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.13
186289882008Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.9
231603702013The neural guidance receptor Plexin C1 delays melanoma progression.7
295142202018Long non-coding RNA CASC2 inhibits tumorigenesis via the miR-181a/PLXNC1 axis in melanoma.2
313173242019MiR-4500 Regulates PLXNC1 and Inhibits Papillary Thyroid Cancer Progression.1

Citation

Dessen P

PLXNC1 (plexin C1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50027/plxnc1