PMPCB (peptidase, mitochondrial processing subunit beta)

2009-09-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
Beta-MPP,MAS1,MPP11,MPPB,MPPP52,P-52
FUSION GENES

Other Information

Locus ID:

NCBI: 9512
MIM: 603131
HGNC: 9119
Ensembl: ENSG00000105819

Variants:

dbSNP: 9512
ClinVar: 9512
TCGA: ENSG00000105819
COSMIC: PMPCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105819ENST00000249269O75439
ENSG00000105819ENST00000428154G3V0E4
ENSG00000105819ENST00000443722F8WBE1
ENSG00000105819ENST00000444457F8WEC8
ENSG00000105819ENST00000453466F8WEA6
ENSG00000105819ENST00000456433F8WAZ6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
223540882012Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.187
249031032014OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase.23
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
295762182018Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood.9
195803452009Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1.2
313376032019PMPCB Silencing Sensitizes HCC Tumor Cells to Sorafenib Therapy.0

Citation

Dessen P

PMPCB (peptidase, mitochondrial processing subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51109/pmpcb