PNCK (pregnancy up-regulated nonubiquitous CaM kinase)

2008-12-01  

Identity

HGNC
PNCK
LOCATION
Xq28
LOCUSID
139728
ALIAS
BSTK3,CaMK1b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 139728
MIM: 300680
HGNC: 13415
Ensembl: ENSG00000130822

Variants:

dbSNP: 139728
ClinVar: 139728
TCGA: ENSG00000130822
COSMIC: PNCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130822ENST00000340888Q6P2M8
ENSG00000130822ENST00000370142Q6P2M8
ENSG00000130822ENST00000370145Q6P2M8
ENSG00000130822ENST00000370150Q6P2M8
ENSG00000130822ENST00000411968F8WBU7
ENSG00000130822ENST00000418241C9J8P0
ENSG00000130822ENST00000419804C9J2B9
ENSG00000130822ENST00000422811C9JB09
ENSG00000130822ENST00000423545C9J2B9
ENSG00000130822ENST00000425526C9J2B9
ENSG00000130822ENST00000433470F8WAQ5
ENSG00000130822ENST00000434652C9JEC5
ENSG00000130822ENST00000438984H7BZQ5
ENSG00000130822ENST00000439087C9JJ18
ENSG00000130822ENST00000447676Q6P2M8
ENSG00000130822ENST00000458354C9J2B9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
330994762020Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.11
330994762020Expression of Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (PNCK) in Hepatocellular Carcinoma.11
257739302015Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.0
257739302015Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.0
236342032013Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.14
236342032013Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.14
213256392011Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.15
213256392011Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.15
185624822008Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.10
185624822008Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.10

Citation

Dessen P

PNCK (pregnancy up-regulated nonubiquitous CaM kinase)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50469/pnck