PNCK (pregnancy up-regulated nonubiquitous CaM kinase)

2008-12-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
BSTK3,CaMK1b
FUSION GENES

Other Information

Locus ID:

NCBI: 139728
MIM: 300680
HGNC: 13415
Ensembl: ENSG00000130822

Variants:

dbSNP: 139728
ClinVar: 139728
TCGA: ENSG00000130822
COSMIC: PNCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130822ENST00000340888Q6P2M8
ENSG00000130822ENST00000370142Q6P2M8
ENSG00000130822ENST00000370145Q6P2M8
ENSG00000130822ENST00000370150Q6P2M8
ENSG00000130822ENST00000411968F8WBU7
ENSG00000130822ENST00000418241C9J8P0
ENSG00000130822ENST00000419804C9J2B9
ENSG00000130822ENST00000422811C9JB09
ENSG00000130822ENST00000423545C9J2B9
ENSG00000130822ENST00000425526C9J2B9
ENSG00000130822ENST00000433470F8WAQ5
ENSG00000130822ENST00000434652C9JEC5
ENSG00000130822ENST00000438984H7BZQ5
ENSG00000130822ENST00000439087C9JJ18
ENSG00000130822ENST00000447676Q6P2M8
ENSG00000130822ENST00000458354C9J2B9

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213256392011Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.11
185624822008Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.8
236342032013Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.7
257739302015Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.4

Citation

Dessen P

PNCK (pregnancy up-regulated nonubiquitous CaM kinase)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50469/pnck