PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene))

2014-11-01  

Identity

HGNC
LOCATION
10q25.3
LOCUSID
ALIAS
PLRP2

Other Information

Locus ID:

NCBI: 5408
MIM: 604423
HGNC: 9157
Ensembl: ENSG00000266200

Variants:

dbSNP: 5408
ClinVar: 5408
TCGA: ENSG00000266200
COSMIC: PNLIPRP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000266200ENST00000591655P54317
ENSG00000266200ENST00000611850A0A087WX88

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Acylglycerol degradationKEGGhsa_M00098
Acylglycerol degradationKEGGM00098
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Digestion of dietary lipidREACTOMER-HSA-192456

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
152877412004Human pancreatic lipase-related protein 2 is a galactolipase.19
174011102007Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.12
216527022011Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.12
218653482011BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line.9
187025142008Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.8
276622542016Lysosomal Lipases PLRP2 and LPLA2 Process Mycobacterial Multi-acylated Lipids and Generate T Cell Stimulatory Antigens.8
237327752013Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.6
168872712006Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA.5
195482712009Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).2

Citation

Dessen P

PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene))

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72023/pnliprp2