PNRC2 (proline rich nuclear receptor coactivator 2)

2019-04-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55629
MIM: 611882
HGNC: 23158
Ensembl: ENSG00000189266

Variants:

dbSNP: 55629
ClinVar: 55629
TCGA: ENSG00000189266
COSMIC: PNRC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189266ENST00000334351Q9NPJ4
ENSG00000189266ENST00000334351A0A024RAC2
ENSG00000189266ENST00000374468Q9NPJ4
ENSG00000189266ENST00000374468A0A024RAC2
ENSG00000189266ENST00000579103J3KS97
ENSG00000189266ENST00000647887Q9NPJ4
ENSG00000189266ENST00000647887A0A024RAC2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191504292009Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex.72
230850782012Structural basis of the PNRC2-mediated link between mrna surveillance and decapping.35
257755142015Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.18
146519672003Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma.9
293481392018Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.8
305511182019MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.3

Citation

Dessen P

PNRC2 (proline rich nuclear receptor coactivator 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57881/pnrc2