PODXL (podocalyxin like)

2007-02-01  

Identity

HGNC
LOCATION
7q32.3
LOCUSID
ALIAS
Gp200,PC,PCLP,PCLP-1,PDX,PODXL1,gp135
FUSION GENES

Other Information

Locus ID:

NCBI: 5420
MIM: 602632
HGNC: 9171
Ensembl: ENSG00000128567

Variants:

dbSNP: 5420
ClinVar: 5420
TCGA: ENSG00000128567
COSMIC: PODXL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128567ENST00000322985O00592
ENSG00000128567ENST00000378555O00592
ENSG00000128567ENST00000446198G3V0E6

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183565742008Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1.81
188183952009The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.62
152893062004Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.60
176166752007Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.56
213836892011Methylation of an intronic region regulates miR-199a in testicular tumor malignancy.55
171240102007The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma.48
218291922011Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.47
203954462010Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal cell carcinoma through recruiting Rac1 guanine nucleotide exchange factor ARHGEF7.44
191181612009Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.43
164344822006Podocalyxin variants and risk of prostate cancer and tumor aggressiveness.40

Citation

Dessen P

PODXL (podocalyxin like)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45807/podxl