Identity
HGNC
LOCATION
Xp22.11
LOCUSID
ALIAS
NSX,POLA,VEODS,p180
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5422
MIM: 312040
HGNC: 9173
Ensembl: ENSG00000101868
Variants:
dbSNP: 5422
ClinVar: 5422
TCGA: ENSG00000101868
COSMIC: POLA1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000101868 | ENST00000379059 | P09884 |
| ENSG00000101868 | ENST00000379068 | A6NMQ1 |
| ENSG00000101868 | ENST00000611764 | A0A087WU64 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33731801 | 2021 | Pol α-primase dependent nuclear localization of the mammalian CST complex. | 11 |
| 34376693 | 2021 | Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini. | 18 |
| 33731801 | 2021 | Pol α-primase dependent nuclear localization of the mammalian CST complex. | 11 |
| 34376693 | 2021 | Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini. | 18 |
| 31006512 | 2019 | Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism. | 17 |
| 31006512 | 2019 | Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism. | 17 |
| 29555682 | 2018 | Activity and fidelity of human DNA polymerase α depend on primer structure. | 18 |
| 29555682 | 2018 | Activity and fidelity of human DNA polymerase α depend on primer structure. | 18 |
| 28320388 | 2017 | Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy. | 8 |
| 28371302 | 2017 | Functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 due to X;6 translocation with an atypical X-inactivation pattern. | 1 |
| 28320388 | 2017 | Exploring the FGFR3-related oncogenic mechanism in bladder cancer using bioinformatics strategy. | 8 |
| 28371302 | 2017 | Functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 due to X;6 translocation with an atypical X-inactivation pattern. | 1 |
| 27019227 | 2016 | DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. | 63 |
| 27019227 | 2016 | DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. | 63 |
| 27032819 | 2016 | Human DNA polymerase α in binary complex with a DNA:DNA template-primer. | 23 |
Citation
Dessen P
POLA1 (DNA polymerase alpha 1, catalytic subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41768/pola1
