Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5427
MIM: 602670
HGNC: 9178
Ensembl: ENSG00000100479
Variants:
dbSNP: 5427
ClinVar: 5427
TCGA: ENSG00000100479
COSMIC: POLE2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100479 | ENST00000216367 | P56282 |
| ENSG00000100479 | ENST00000539565 | P56282 |
| ENSG00000100479 | ENST00000553805 | U3KQ22 |
| ENSG00000100479 | ENST00000554396 | P56282 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37097331 | 2024 | POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/β-catenin signaling pathway. | 0 |
| 38070189 | 2024 | Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway. | 3 |
| 38963027 | 2024 | The Prognostic Hub Gene POLE2 Promotes BLCA Cell Growth via the PI3K/AKT Signaling Pathway. | 0 |
| 37097331 | 2024 | POLE2 knockdown suppresses lymphoma progression via downregulating Wnt/β-catenin signaling pathway. | 0 |
| 38070189 | 2024 | Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway. | 3 |
| 38963027 | 2024 | The Prognostic Hub Gene POLE2 Promotes BLCA Cell Growth via the PI3K/AKT Signaling Pathway. | 0 |
| 37657752 | 2023 | Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels. | 1 |
| 38079056 | 2023 | POLE2 Regulates Apoptosis of Oral Squamous Cell Carcinoma Cells through the PI3K/AKT Signaling Pathway. | 0 |
| 37657752 | 2023 | Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in NSCLC cells by increasing SP1 acetylation levels. | 1 |
| 38079056 | 2023 | POLE2 Regulates Apoptosis of Oral Squamous Cell Carcinoma Cells through the PI3K/AKT Signaling Pathway. | 0 |
| 35039475 | 2022 | POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1. | 12 |
| 35039475 | 2022 | POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1. | 12 |
| 32740585 | 2020 | Genetic Risk of Trigger Finger: Results of a Genomewide Association Study. | 3 |
| 32740585 | 2020 | Genetic Risk of Trigger Finger: Results of a Genomewide Association Study. | 3 |
| 25924900 | 2015 | DNA Polymerases as targets for gene therapy of hepatocellular carcinoma. | 5 |
Citation
Dessen P
POLE2 (DNA polymerase epsilon 2, accessory subunit)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41774/pole2
