POLK (DNA polymerase kappa)

2004-04-01  

Identity

HGNC
LOCATION
5q13.3
LOCUSID
ALIAS
DINB1,DINP,POLQ

Other Information

Locus ID:

NCBI: 51426
MIM: 605650
HGNC: 9183
Ensembl: ENSG00000122008

Variants:

dbSNP: 51426
ClinVar: 51426
TCGA: ENSG00000122008
COSMIC: POLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122008ENST00000241436Q9UBT6
ENSG00000122008ENST00000241436A0A024RAP4
ENSG00000122008ENST00000503479D6RAE5
ENSG00000122008ENST00000504026Q9UBT6
ENSG00000122008ENST00000505774D6RAI7
ENSG00000122008ENST00000505975D6RAI7
ENSG00000122008ENST00000508526Q9UBT6
ENSG00000122008ENST00000509126Q9UBT6
ENSG00000122008ENST00000510815Q9UBT6
ENSG00000122008ENST00000511527D6RAI7
ENSG00000122008ENST00000514141D6R9M8
ENSG00000122008ENST00000514296D6RDX9
ENSG00000122008ENST00000515295Q9UBT6

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by POLKREACTOMER-HSA-5655862
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210

References

Pubmed IDYearTitleCitations
173176312007Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass.134
151894462004Interaction of hREV1 with three human Y-family DNA polymerases.99
167511962006Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa.76
166119942006Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest.72
158174572005DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint.64
151991272004Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191170142009Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.60
124442492002Role of human DNA polymerase kappa as an extender in translesion synthesis.57
118421892002Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini.51

Citation

Dessen P

POLK (DNA polymerase kappa)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/41777/polk