Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10721
MIM: 604419
HGNC: 9186
Ensembl: ENSG00000051341
Variants:
dbSNP: 10721
ClinVar: 10721
TCGA: ENSG00000051341
COSMIC: POLQ
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000051341 | ENST00000264233 | O75417 |
| ENSG00000051341 | ENST00000621776 | A0A087WXL3 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38270643 | 2024 | The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance. | 1 |
| 38575587 | 2024 | POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase. | 0 |
| 38640889 | 2024 | Human DNA polymerase θ does not harbor intrinsic nuclease activity. | 2 |
| 38671548 | 2024 | Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity. | 0 |
| 38782541 | 2024 | Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model. | 0 |
| 38270643 | 2024 | The m(6)A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance. | 1 |
| 38575587 | 2024 | POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase. | 0 |
| 38640889 | 2024 | Human DNA polymerase θ does not harbor intrinsic nuclease activity. | 2 |
| 38671548 | 2024 | Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity. | 0 |
| 38782541 | 2024 | Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model. | 0 |
| 35737091 | 2023 | Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ. | 2 |
| 37153990 | 2023 | [Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells]. | 0 |
| 37674080 | 2023 | Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. | 18 |
| 35737091 | 2023 | Whole-exome sequencing of Indian prostate cancer reveals a novel therapeutic target: POLQ. | 2 |
| 37153990 | 2023 | [Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells]. | 0 |
Citation
Dessen P
POLQ (DNA polymerase theta)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/41779/polq
