POLR2B (RNA polymerase II subunit B)

2010-12-01 Affiliation

Identity

HGNC

POLR2B

LOCATION

4q12

LOCUSID

5431

ALIAS

POL2RB,RPB2,hRPB140

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5431
MIM: 180661
HGNC: 9188
Ensembl: ENSG00000047315

Variants:

dbSNP: 5431
ClinVar: 5431
TCGA: ENSG00000047315
COSMIC: POLR2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000047315	ENST00000314595	P30876
ENSG00000047315	ENST00000381227	P30876
ENSG00000047315	ENST00000431623	C9J4M6
ENSG00000047315	ENST00000433463	C9JZW8
ENSG00000047315	ENST00000441246	C9J2Y9
ENSG00000047315	ENST00000450656	C9JMN3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Pyrimidine metabolism	KEGG	ko00240
RNA polymerase	KEGG	ko03020
Huntington's disease	KEGG	ko05016
Purine metabolism	KEGG	hsa00230
Pyrimidine metabolism	KEGG	hsa00240
RNA polymerase	KEGG	hsa03020
Huntington's disease	KEGG	hsa05016
Metabolic pathways	KEGG	hsa01100
RNA polymerase II, eukaryotes	KEGG	hsa_M00180
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
RNA polymerase II, eukaryotes	KEGG	M00180
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
FGFR2 mutant receptor activation	REACTOME	R-HSA-1839126
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Initiation	REACTOME	R-HSA-167161
RNA Polymerase II HIV Promoter Escape	REACTOME	R-HSA-167162
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	REACTOME	R-HSA-167160
HIV Transcription Elongation	REACTOME	R-HSA-167169
Formation of the HIV-1 Early Elongation Complex	REACTOME	R-HSA-167158
Tat-mediated elongation of the HIV-1 transcript	REACTOME	R-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 Tat	REACTOME	R-HSA-167200
Abortive elongation of HIV-1 transcript in the absence of Tat	REACTOME	R-HSA-167242
HIV elongation arrest and recovery	REACTOME	R-HSA-167287
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Pausing and recovery of HIV elongation	REACTOME	R-HSA-167290
Tat-mediated HIV elongation arrest and recovery	REACTOME	R-HSA-167243
Pausing and recovery of Tat-mediated HIV elongation	REACTOME	R-HSA-167238
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral Messenger RNA Synthesis	REACTOME	R-HSA-168325
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	REACTOME	R-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter Clearance	REACTOME	R-HSA-76042
RNA Polymerase II Transcription Initiation	REACTOME	R-HSA-75953
RNA Polymerase II Promoter Escape	REACTOME	R-HSA-73776
RNA Pol II CTD phosphorylation and interaction with CE	REACTOME	R-HSA-77075
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of the Early Elongation Complex	REACTOME	R-HSA-113418
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
mRNA Capping	REACTOME	R-HSA-72086
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
mRNA Splicing - Minor Pathway	REACTOME	R-HSA-72165
Gene Silencing by RNA	REACTOME	R-HSA-211000
MicroRNA (miRNA) biogenesis	REACTOME	R-HSA-203927
Transcriptional regulation by small RNAs	REACTOME	R-HSA-5578749
PIWI-interacting RNA (piRNA) biogenesis	REACTOME	R-HSA-5601884
Developmental Biology	REACTOME	R-HSA-1266738
Transcriptional regulation of pluripotent stem cells	REACTOME	R-HSA-452723
DNA Repair	REACTOME	R-HSA-73894
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	REACTOME	R-HSA-6781827
Formation of TC-NER Pre-Incision Complex	REACTOME	R-HSA-6781823
Dual incision in TC-NER	REACTOME	R-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NER	REACTOME	R-HSA-6782210
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472
FGFR2 alternative splicing	REACTOME	R-HSA-6803529
Signaling by FGFR2 IIIa TM	REACTOME	R-HSA-8851708
TP53 Regulates Transcription of DNA Repair Genes	REACTOME	R-HSA-6796648
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37423037	2023	The RNA polymerase II subunit B (RPB2) functions as a growth regulator in human glioblastoma.	2
37423037	2023	The RNA polymerase II subunit B (RPB2) functions as a growth regulator in human glioblastoma.	2
34060620	2021	ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.	6
34060620	2021	ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.	6
21081187	2011	Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.	159
21081187	2011	Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.	159
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19237606	2009	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	14
19237606	2009	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	14
17494052	2007	Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.	41
17499043	2007	Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.	79
17584298	2007	Hepatitis delta antigen binds to the clamp of RNA polymerase II and affects transcriptional fidelity.	26
17494052	2007	Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.	41
17499043	2007	Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.	79

Citation

Dessen P

POLR2B (RNA polymerase II subunit B)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51774/polr2b

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