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POLR2M (RNA polymerase II subunit M)

Identity

Alias (NCBI)GCOM1
GRINL1A
Gdown
Gdown1
HGNC (Hugo) POLR2M
HGNC Alias symbGdown
Gdown1
GCOM1
HGNC Previous nameGRINL1A
HGNC Previous nameglutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
 polymerase (RNA) II (DNA directed) polypeptide M
 polymerase (RNA) II subunit M
LocusID (NCBI) 81488
Atlas_Id 72054
Location 15q21.3  [Link to chromosome band 15q21]
Location_base_pair Starts at 57706521 and ends at 57717557 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLR2M (15q21.3) / ADGRL1 (19p13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;19)(q21;p13) POLR2M/ADGRL1

External links

Nomenclature
HGNC (Hugo)POLR2M   14862
Cards
Entrez_Gene (NCBI)POLR2M    RNA polymerase II subunit M
AliasesGCOM1; GRINL1A; Gdown; Gdown1
GeneCards (Weizmann)POLR2M
Ensembl hg19 (Hinxton)ENSG00000255529 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000255529 [Gene_View]  ENSG00000255529 [Sequence]  chr15:57706521-57717557 [Contig_View]  POLR2M [Vega]
ICGC DataPortalENSG00000255529
TCGA cBioPortalPOLR2M
AceView (NCBI)POLR2M
Genatlas (Paris)POLR2M
SOURCE (Princeton)POLR2M
Genetics Home Reference (NIH)POLR2M
Genomic and cartography
GoldenPath hg38 (UCSC)POLR2M  -     chr15:57706521-57717557 +  15q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)POLR2M  -     15q21.3   [Description]    (hg19-Feb_2009)
GoldenPathPOLR2M - 15q21.3 [CytoView hg19]  POLR2M - 15q21.3 [CytoView hg38]
ImmunoBaseENSG00000255529
genome Data Viewer NCBIPOLR2M [Mapview hg19]  
OMIM606485   
Gene and transcription
Genbank (Entrez)AF086209 AF326773 AK074767 AK074955 AK128618
RefSeq transcript (Entrez)NM_001018102 NM_015532
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)POLR2M
Alternative Splicing GalleryENSG00000255529
Gene ExpressionPOLR2M [ NCBI-GEO ]   POLR2M [ EBI - ARRAY_EXPRESS ]   POLR2M [ SEEK ]   POLR2M [ MEM ]
Gene Expression Viewer (FireBrowse)POLR2M [ Firebrowse - Broad ]
GenevisibleExpression of POLR2M in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81488
GTEX Portal (Tissue expression)POLR2M
Human Protein AtlasENSG00000255529-POLR2M [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6EEV4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6EEV4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6EEV4
Splice isoforms : SwissVarQ6EEV4
PhosPhoSitePlusQ6EEV4
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)POLR2M
Blocks (Seattle)POLR2M
SuperfamilyQ6EEV4
Human Protein Atlas [tissue]ENSG00000255529-POLR2M [tissue]
Peptide AtlasQ6EEV4
HPRD07575
IPIIPI00552141   IPI00443687   IPI00816688   IPI00455444   IPI00455446   IPI00936485   
Protein Interaction databases
DIP (DOE-UCLA)Q6EEV4
IntAct (EBI)Q6EEV4
BioGRIDPOLR2M
STRING (EMBL)POLR2M
ZODIACPOLR2M
Ontologies - Pathways
QuickGOQ6EEV4
Ontology : AmiGODNA-directed 5'-3' RNA polymerase activity  nuclear envelope  RNA polymerase II, holoenzyme  RNA biosynthetic process  neuronal cell body  maintenance of ER location  
Ontology : EGO-EBIDNA-directed 5'-3' RNA polymerase activity  nuclear envelope  RNA polymerase II, holoenzyme  RNA biosynthetic process  neuronal cell body  maintenance of ER location  
NDEx NetworkPOLR2M
Atlas of Cancer Signalling NetworkPOLR2M
Wikipedia pathwaysPOLR2M
Orthology - Evolution
OrthoDB81488
GeneTree (enSembl)ENSG00000255529
Phylogenetic Trees/Animal Genes : TreeFamPOLR2M
HOGENOMQ6EEV4
Homologs : HomoloGenePOLR2M
Homology/Alignments : Family Browser (UCSC)POLR2M
Gene fusions - Rearrangements
Fusion : QuiverPOLR2M
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPOLR2M [hg38]
dbVarPOLR2M
ClinVarPOLR2M
MonarchPOLR2M
1000_GenomesPOLR2M 
Exome Variant ServerPOLR2M
GNOMAD BrowserENSG00000255529
Varsome BrowserPOLR2M
Genomic Variants (DGV)POLR2M [DGVbeta]
DECIPHERPOLR2M [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPOLR2M 
Mutations
ICGC Data PortalPOLR2M 
TCGA Data PortalPOLR2M 
Broad Tumor PortalPOLR2M
OASIS PortalPOLR2M [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPOLR2M  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPOLR2M
Mutations and Diseases : HGMDPOLR2M
BioMutasearch POLR2M
DgiDB (Drug Gene Interaction Database)POLR2M
DoCM (Curated mutations)POLR2M (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)POLR2M (select a term)
intoGenPOLR2M
Cancer3DPOLR2M(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606485   
Orphanet
DisGeNETPOLR2M
MedgenPOLR2M
Genetic Testing Registry POLR2M
NextProtQ6EEV4 [Medical]
GENETestsPOLR2M
Target ValidationPOLR2M
Huge Navigator POLR2M [HugePedia]
ClinGenPOLR2M
Clinical trials, drugs, therapy
MyCancerGenomePOLR2M
Protein Interactions : CTD
Pharm GKB GenePA28986
Clinical trialPOLR2M
Miscellaneous
canSAR (ICR)POLR2M (select the gene name)
HarmonizomePOLR2M
DataMed IndexPOLR2M
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePOLR2M
EVEXPOLR2M
GoPubMedPOLR2M
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Dec 5 17:23:03 CET 2020
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