POLR3G (RNA polymerase III subunit G)

2016-10-01  

Identity

HGNC
LOCATION
5q14.3
LOCUSID
ALIAS
C31,RPC32,RPC7

Other Information

Locus ID:

NCBI: 10622
MIM: 617456
HGNC: 30075
Ensembl: ENSG00000113356

Variants:

dbSNP: 10622
ClinVar: 10622
TCGA: ENSG00000113356
COSMIC: POLR3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113356ENST00000399107O15318
ENSG00000113356ENST00000399107A0A024RAM1
ENSG00000113356ENST00000503373D6R9U7
ENSG00000113356ENST00000503973D6R921
ENSG00000113356ENST00000504930O15318
ENSG00000113356ENST00000504930A0A024RAM1
ENSG00000113356ENST00000505345D6RIT0
ENSG00000113356ENST00000512239D6REQ0
ENSG00000113356ENST00000514483D6RJH6
ENSG00000113356ENST00000651687O15318
ENSG00000113356ENST00000651687A0A024RAM1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
RNA polymeraseKEGGko03020
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
RNA polymeraseKEGGhsa03020
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Metabolic pathwaysKEGGhsa01100
RNA polymerase III, eukaryotesKEGGhsa_M00181
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
RNA polymerase III, eukaryotesKEGGM00181
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066
RNA Polymerase III Transcription Initiation From Type 3 PromoterREACTOMER-HSA-76071
RNA Polymerase III Chain ElongationREACTOMER-HSA-73780
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447230HIVDiseaseClinicalAnnotationassociatedPD21810746
PA450616nevirapineChemicalClinicalAnnotationassociatedPD21810746

References

Pubmed IDYearTitleCitations
218986822011A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.15
308205482019Effects on prostate cancer cells of targeting RNA polymerase III.2
284949422017RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.1

Citation

Dessen P

POLR3G (RNA polymerase III subunit G)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55969/polr3g