PON3 (paraoxonase 3)

2013-07-01  

Identity

HGNC
LOCATION
7q21.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 5446
MIM: 602720
HGNC: 9206
Ensembl: ENSG00000105852

Variants:

dbSNP: 5446
ClinVar: 5446
TCGA: ENSG00000105852
COSMIC: PON3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105852ENST00000265627Q15166
ENSG00000105852ENST00000418617F2Z2L3
ENSG00000105852ENST00000427422C9JZ99
ENSG00000105852ENST00000442770F2Z2L3
ENSG00000105852ENST00000451904F8WD41
ENSG00000105852ENST00000456855F8WBV4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157724232005Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities.167
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
209341782011The three-gene paraoxonase family: physiologic roles, actions and regulation.63
146958842004Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.50
183470342008Dominant role of paraoxonases in inactivation of the Pseudomonas aeruginosa quorum-sensing signal N-(3-oxododecanoyl)-L-homoserine lactone.38
168229642006Paraoxonase cluster polymorphisms are associated with sporadic ALS.31
168229642006Paraoxonase cluster polymorphisms are associated with sporadic ALS.31
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.30
125887792003Extensive association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese Han population.28
224416692012PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.28

Citation

Dessen P

PON3 (paraoxonase 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53436/pon3