Identity
HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
CPR,CYPOR,P450R
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5447
MIM: 124015
HGNC: 9208
Ensembl: ENSG00000127948
Variants:
dbSNP: 5447
ClinVar: 5447
TCGA: ENSG00000127948
COSMIC: POR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA151958383 | Gastrointestinal Stromal Tumors | Disease | ClinicalAnnotation | associated | PD | 28117434 | |
| PA162372840 | sunitinib | Chemical | ClinicalAnnotation | associated | PD | 28117434 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PK | PD | 21770725, 23097010, 23974086, 24061445, 24113216, 24658827, 24739669, 24921414, 25271728, 25322286, 26227094, 26829596, 28094348, 29135906, 29399716, 29878980, 30323313 |
| PA166114942 | familial hypercholesterolemia | Disease | ClinicalAnnotation | associated | PD | 25521355 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 25521355 | |
| PA449167 | cyclosporine | Chemical | ClinicalAnnotation | associated | PK | 24061445, 24658827, 29135906 | |
| PA450496 | midazolam | Chemical | ClinicalAnnotation | associated | PK | 19801957, 23324807 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PK | ||
| PA451365 | sirolimus | Chemical | ClinicalAnnotation | associated | PK | 23974086 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK | PD | 21770725, 23097010, 24061445, 24113216, 24739669, 24921414, 25271728, 25322286, 26227094, 26829596, 28094348, 29399716, 29878980, 30323313 |
| PA451906 | warfarin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 27488389 | |
| PA451954 | zidovudine | Chemical | Pathway | associated | 22960662 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36321415 | 2023 | POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway. | 1 |
| 36951964 | 2023 | Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation. | 0 |
| 37509119 | 2023 | Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism. | 3 |
| 37517692 | 2023 | Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain. | 1 |
| 36321415 | 2023 | POR overexpression induces tamoxifen-resistance in breast cancer through the STAT1/c-Myc pathway. | 1 |
| 36951964 | 2023 | Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation. | 0 |
| 37509119 | 2023 | Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism. | 3 |
| 37517692 | 2023 | Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain. | 1 |
| 35164791 | 2022 | The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. | 3 |
| 35889519 | 2022 | In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase. | 0 |
| 35164791 | 2022 | The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. | 3 |
| 35889519 | 2022 | In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase. | 0 |
| 33011882 | 2021 | Microsomal reductase activity in patients with thyroid neoplasms. | 5 |
| 33321093 | 2021 | Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1. | 182 |
| 33420418 | 2021 | An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase. | 10 |
Citation
Dessen P
POR (cytochrome p450 oxidoreductase)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41787/por
