POU2F2 (POU class 2 homeobox 2)

2007-02-01 Affiliation

Identity

HGNC

POU2F2

LOCATION

19q13.2

LOCUSID

5452

ALIAS

OCT2,OTF2,Oct-2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5452
MIM: 164176
HGNC: 9213
Ensembl: ENSG00000028277

Variants:

dbSNP: 5452
ClinVar: 5452
TCGA: ENSG00000028277
COSMIC: POU2F2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000028277	ENST00000342301	B5ME60
ENSG00000028277	ENST00000389341	P09086
ENSG00000028277	ENST00000524801	A0A1B0GV81
ENSG00000028277	ENST00000526816	P09086
ENSG00000028277	ENST00000526831	U3KQN1
ENSG00000028277	ENST00000528894	U3KQ96
ENSG00000028277	ENST00000529067	P09086
ENSG00000028277	ENST00000529952	P09086
ENSG00000028277	ENST00000532176	A0A1B0GW97
ENSG00000028277	ENST00000533548	H0YNG1
ENSG00000028277	ENST00000534559	E9PR37
ENSG00000028277	ENST00000560398	H0YLL6
ENSG00000028277	ENST00000560558	H0YNW1
ENSG00000028277	ENST00000560804	H0YKT2
ENSG00000028277	ENST00000598842	M0R1I6
ENSG00000028277	ENST00000625670	A0A0D9SF23
ENSG00000028277	ENST00000636631	A0A1B0GUT9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19625999	2009	Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.	94
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19536068	2009	The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.	68
24435047	2014	Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.	58
22346751	2012	The B-cell specific transcription factor, Oct-2, promotes Epstein-Barr virus latency by inhibiting the viral immediate-early protein, BZLF1.	21
19270158	2009	A high throughput embryonic stem cell screen identifies Oct-2 as a bifunctional regulator of neuronal differentiation.	20
18695675	2008	Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells.	19
14707079	2004	NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells.	17
26019213	2016	POU2F2-oriented network promotes human gastric cancer metastasis.	15
16186795	2006	Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.	13

Citation

Dessen P

POU2F2 (POU class 2 homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46573/pou2f2