POU4F2 (POU class 4 homeobox 2)

2003-02-01  

Identity

HGNC
LOCATION
4q31.22
LOCUSID
ALIAS
BRN3.2,BRN3B,Brn-3b

Other Information

Locus ID:

NCBI: 5458
MIM: 113725
HGNC: 9219
Ensembl: ENSG00000151615

Variants:

dbSNP: 5458
ClinVar: 5458
TCGA: ENSG00000151615
COSMIC: POU4F2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151615ENST00000281321Q12837

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through Association with Co-factorsREACTOMER-HSA-6804759

References

Pubmed IDYearTitleCitations
183676062008A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors.39
230562782012Diagnosis of bladder cancer recurrence based on urinary levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 hypermethylation.37
159680822005Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.22
267006202016An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese.18
147266992004Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor.16
158338362005Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.15
149702342004The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo.13
176377572008Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells.11
161525972006The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells.8
174906552007Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells.5

Citation

Dessen P

POU4F2 (POU class 4 homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41788/pou4f2