Identity
HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
NR1C1,PPAR,PPAR-alpha,PPARalpha,hPPAR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5465
MIM: 170998
HGNC: 9232
Ensembl: ENSG00000186951
Variants:
dbSNP: 5465
ClinVar: 5465
TCGA: ENSG00000186951
COSMIC: PPARA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA133888799 | Organ Transplantation | Disease | ClinicalAnnotation | associated | PK | 24658827 | |
| PA162370415 | Metabolic Syndrome | Disease | VariantAnnotation | not associated | PD | ||
| PA164712535 | Beta Blocking Agents | Chemical | ClinicalAnnotation | associated | PD | 18855529 | |
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 24113216, 29399716 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 18855529 | |
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PD | 15608561, 24853734 | |
| PA447216 | Schizophrenia | Disease | VariantAnnotation | not associated | PD | ||
| PA449061 | clozapine | Chemical | VariantAnnotation | not associated | PD | ||
| PA449594 | fenofibrate | Chemical | ClinicalAnnotation | associated | PD | 15608561 | |
| PA450395 | metformin | Chemical | ClinicalAnnotation | associated | PD | 24853734 | |
| PA450921 | phenprocoumon | Chemical | ClinicalAnnotation | associated | PD | 25461249 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 23252946, 23930676, 24598718 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PK | PD | 24113216, 24658827, 29399716 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37926201 | 2024 | The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα. | 0 |
| 38167146 | 2024 | Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury. | 0 |
| 39000217 | 2024 | Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy. | 0 |
| 37926201 | 2024 | The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα. | 0 |
| 38167146 | 2024 | Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury. | 0 |
| 39000217 | 2024 | Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy. | 0 |
| 35459765 | 2023 | Association of placental PPARα/γ and miR-27b expression with macrosomia in healthy pregnancy. | 1 |
| 35460276 | 2023 | Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis. | 31 |
| 36305579 | 2023 | Therapeutic roles of PPARα activation in ocular ischemic diseases. | 4 |
| 36626642 | 2023 | Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. | 4 |
| 36812713 | 2023 | The emerging role of PPAR-alpha in breast cancer. | 4 |
| 37204637 | 2023 | miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. | 0 |
| 37286039 | 2023 | Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. | 2 |
| 37482742 | 2023 | [Preliminary study of PPARA regulate the ferroptosis of hepatocellular carcinoma to prevent disease deterioration]. | 0 |
| 37805161 | 2023 | MiR-455-3p mediates PPARα through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells. | 0 |
Citation
Dessen P
PPARA (peroxisome proliferator activated receptor alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41792/ppara
