Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPBP (pro-platelet basic protein)

Identity

Alias_namesTHBGB1
Alias_symbol (synonym)SCYB7
TGB
NAP-2-L1
LA-PF4
MDGF
LDGF
Beta-TG
CTAP3
CXCL7
PBP
b-TG1
TGB1
CTAPIII
NAP-2
Other aliasB-TG1
CTAP-III
TC1
TC2
THBGB
HGNC (Hugo) PPBP
LocusID (NCBI) 5473
Atlas_Id 51614
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 73986439 and ends at 73988190 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPBP   9240
Cards
Entrez_Gene (NCBI)PPBP  5473  pro-platelet basic protein
AliasesB-TG1; Beta-TG; CTAP-III; CTAP3; 
CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
GeneCards (Weizmann)PPBP
Ensembl hg19 (Hinxton)ENSG00000163736 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163736 [Gene_View]  ENSG00000163736 [Sequence]  chr4:73986439-73988190 [Contig_View]  PPBP [Vega]
ICGC DataPortalENSG00000163736
TCGA cBioPortalPPBP
AceView (NCBI)PPBP
Genatlas (Paris)PPBP
WikiGenes5473
SOURCE (Princeton)PPBP
Genetics Home Reference (NIH)PPBP
Genomic and cartography
GoldenPath hg38 (UCSC)PPBP  -     chr4:73986439-73988190 -  4q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPBP  -     4q13.3   [Description]    (hg19-Feb_2009)
GoldenPathPPBP - 4q13.3 [CytoView hg19]  PPBP - 4q13.3 [CytoView hg38]
ImmunoBaseENSG00000163736
Mapping of homologs : NCBIPPBP [Mapview hg19]  PPBP [Mapview hg38]
OMIM121010   
Gene and transcription
Genbank (Entrez)AK312166 BC028217 BQ447470 BX443846 CB112845
RefSeq transcript (Entrez)NM_002704
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPBP
Cluster EST : UnigeneHs.2164 [ NCBI ]
CGAP (NCI)Hs.2164
Alternative Splicing GalleryENSG00000163736
Gene ExpressionPPBP [ NCBI-GEO ]   PPBP [ EBI - ARRAY_EXPRESS ]   PPBP [ SEEK ]   PPBP [ MEM ]
Gene Expression Viewer (FireBrowse)PPBP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5473
GTEX Portal (Tissue expression)PPBP
Human Protein AtlasENSG00000163736-PPBP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02775
Splice isoforms : SwissVarP02775
PhosPhoSitePlusP02775
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom    CXC_Chemokine_domain    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)PPBP
DMDM Disease mutations5473
Blocks (Seattle)PPBP
PDB (RSDB)1F9P    1NAP    1TVX   
PDB Europe1F9P    1NAP    1TVX   
PDB (PDBSum)1F9P    1NAP    1TVX   
PDB (IMB)1F9P    1NAP    1TVX   
Structural Biology KnowledgeBase1F9P    1NAP    1TVX   
SCOP (Structural Classification of Proteins)1F9P    1NAP    1TVX   
CATH (Classification of proteins structures)1F9P    1NAP    1TVX   
SuperfamilyP02775
Human Protein Atlas [tissue]ENSG00000163736-PPBP [tissue]
Peptide AtlasP02775
HPRD07171
IPIIPI00022445   
Protein Interaction databases
DIP (DOE-UCLA)P02775
IntAct (EBI)P02775
FunCoupENSG00000163736
BioGRIDPPBP
STRING (EMBL)PPBP
ZODIACPPBP
Ontologies - Pathways
QuickGOP02775
Ontology : AmiGOplatelet degranulation  glucose transmembrane transporter activity  protein binding  extracellular region  extracellular space  inflammatory response  immune response  G protein-coupled receptor signaling pathway  chemokine activity  growth factor activity  neutrophil chemotaxis  leukocyte chemotaxis  platelet alpha granule lumen  defense response to bacterium  neutrophil degranulation  positive regulation of cell division  antimicrobial humoral immune response mediated by antimicrobial peptide  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  glucose transmembrane transport  tertiary granule lumen  
Ontology : EGO-EBIplatelet degranulation  glucose transmembrane transporter activity  protein binding  extracellular region  extracellular space  inflammatory response  immune response  G protein-coupled receptor signaling pathway  chemokine activity  growth factor activity  neutrophil chemotaxis  leukocyte chemotaxis  platelet alpha granule lumen  defense response to bacterium  neutrophil degranulation  positive regulation of cell division  antimicrobial humoral immune response mediated by antimicrobial peptide  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  glucose transmembrane transport  tertiary granule lumen  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkPPBP
Atlas of Cancer Signalling NetworkPPBP
Wikipedia pathwaysPPBP
Orthology - Evolution
OrthoDB5473
GeneTree (enSembl)ENSG00000163736
Phylogenetic Trees/Animal Genes : TreeFamPPBP
HOGENOMP02775
Homologs : HomoloGenePPBP
Homology/Alignments : Family Browser (UCSC)PPBP
Gene fusions - Rearrangements
Fusion : QuiverPPBP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPBP
dbVarPPBP
ClinVarPPBP
1000_GenomesPPBP 
Exome Variant ServerPPBP
ExAC (Exome Aggregation Consortium)ENSG00000163736
GNOMAD BrowserENSG00000163736
Varsome BrowserPPBP
Genetic variants : HAPMAP5473
Genomic Variants (DGV)PPBP [DGVbeta]
DECIPHERPPBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPBP 
Mutations
ICGC Data PortalPPBP 
TCGA Data PortalPPBP 
Broad Tumor PortalPPBP
OASIS PortalPPBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPBP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPBP
Mutations and Diseases : HGMDPPBP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPBP
DgiDB (Drug Gene Interaction Database)PPBP
DoCM (Curated mutations)PPBP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPBP (select a term)
intoGenPPBP
Cancer3DPPBP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM121010   
Orphanet
DisGeNETPPBP
MedgenPPBP
Genetic Testing Registry PPBP
NextProtP02775 [Medical]
TSGene5473
GENETestsPPBP
Target ValidationPPBP
Huge Navigator PPBP [HugePedia]
snp3D : Map Gene to Disease5473
BioCentury BCIQPPBP
ClinGenPPBP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5473
Chemical/Pharm GKB GenePA33561
Clinical trialPPBP
Miscellaneous
canSAR (ICR)PPBP (select the gene name)
DataMed IndexPPBP
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPBP
EVEXPPBP
GoPubMedPPBP
iHOPPPBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:01:56 CET 2019
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