PPIF (peptidylprolyl isomerase F)

2019-04-01  

Identity

HGNC
LOCATION
10q22.3
LOCUSID
ALIAS
CYP3,CyP-M,Cyp-D,CypD
FUSION GENES

Other Information

Locus ID:

NCBI: 10105
MIM: 604486
HGNC: 9259
Ensembl: ENSG00000108179

Variants:

dbSNP: 10105
ClinVar: 10105
TCGA: ENSG00000108179
COSMIC: PPIF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108179ENST00000225174P30405
ENSG00000108179ENST00000225174A0A024QZS4
ENSG00000108179ENST00000448165H0Y548
ENSG00000108179ENST00000472580R4GN99

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
209781882010Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
263877352015SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore.57
120771162002Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization.41
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
197356412009Redox characterization of human cyclophilin D: identification of a new mammalian mitochondrial redox sensor?30
254457072015Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore.27
220130522012Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.25
283780422017Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?23

Citation

Dessen P

PPIF (peptidylprolyl isomerase F)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57966/ppif