PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1)

2014-11-01  

Identity

HGNC
PPIP5K1
LOCATION
15q15.3
LOCUSID
9677
ALIAS
HISPPD2A,IP6K,IPS1,VIP1,hsVIP1

Other Information

Locus ID:

NCBI: 9677
MIM: 610979
HGNC: 29023
Ensembl: ENSG00000168781

Variants:

dbSNP: 9677
ClinVar: 9677
TCGA: ENSG00000168781
COSMIC: PPIP5K1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168781ENST00000334933Q6PFW1
ENSG00000168781ENST00000348806Q6PFW1
ENSG00000168781ENST00000360135Q6PFW1
ENSG00000168781ENST00000360301Q6PFW1
ENSG00000168781ENST00000381879F8W9A8
ENSG00000168781ENST00000381885B7WPL9
ENSG00000168781ENST00000396923Q6PFW1
ENSG00000168781ENST00000417085C9J5E6
ENSG00000168781ENST00000420765Q6PFW1
ENSG00000168781ENST00000427877H7C436
ENSG00000168781ENST00000429176C9J5E6
ENSG00000168781ENST00000431962C9J490
ENSG00000168781ENST00000437065H7C398
ENSG00000168781ENST00000439195H0Y3Y5
ENSG00000168781ENST00000453080C9JZX6
ENSG00000168781ENST00000644537A0A2R8YGT1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Phosphatidylinositol signaling systemKEGGko04070
Phosphatidylinositol signaling systemKEGGhsa04070
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of pyrophosphates in the cytosolREACTOMER-HSA-1855167

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
212226532011Receptor-dependent compartmentalization of PPIP5K1, a kinase with a cryptic polyphosphoinositide binding domain.22
281269032017The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.19
277769742017The significance of the 1-kinase/1-phosphatase activities of the PPIP5K family.10
268546142016PPIP5K1 interacts with the exocyst complex through a C-terminal intrinsically disordered domain and regulates cell motility.8

Citation

Dessen P

PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72136/ppip5k1