PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)

2007-04-01  

Identity

HGNC
PPM1B
LOCATION
2p21
LOCUSID
5495
ALIAS
PP2C-beta,PP2C-beta-X,PP2CB,PP2CBETA,PPC2BETAX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5495
MIM: 603770
HGNC: 9276
Ensembl: ENSG00000138032

Variants:

dbSNP: 5495
ClinVar: 5495
TCGA: ENSG00000138032
COSMIC: PPM1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138032ENST00000282412O75688
ENSG00000138032ENST00000345249O75688
ENSG00000138032ENST00000378551O75688
ENSG00000138032ENST00000409432O75688
ENSG00000138032ENST00000409473B8ZZF0
ENSG00000138032ENST00000419807C9JIR6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
188294612008Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.40
189301332009PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.39
145858472004Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.27
239035852013Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.19
227502912012PPM1B negatively regulates antiviral response via dephosphorylating TBK1.18
233205002013The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.12
264940002016miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition.10
223930502012Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.8
237568132013PKA negatively regulates PP2Cβ to activate NF-κB-mediated inflammatory signaling.8

Citation

Dessen P

PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46724/ppm1b