PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)

2006-10-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
CAMKPN,CaMKP-N,POPX1,PP2CH,caMKN
FUSION GENES

Other Information

Locus ID:

NCBI: 22843
HGNC: 19322
Ensembl: ENSG00000175175

Variants:

dbSNP: 22843
ClinVar: 22843
TCGA: ENSG00000175175
COSMIC: PPM1E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175175ENST00000308249Q8WY54

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118645732002The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.39
208012142011Ppm1E is an in cellulo AMP-activated protein kinase phosphatase.30
276611142016miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone.19
277930012016miR-135b-5p inhibits LPS-induced TNFα production via silencing AMPK phosphatase Ppm1e.13
284237192017AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.6
284604352017microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation.5

Citation

Dessen P

PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43424/ppm1e