PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F)

2006-10-01  

Identity

HGNC
PPM1F
LOCATION
22q11.22
LOCUSID
9647
ALIAS
CAMKP,CaMKPase,FEM-2,POPX2,hFEM-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9647
HGNC: 19388
Ensembl: ENSG00000100034

Variants:

dbSNP: 9647
ClinVar: 9647
TCGA: ENSG00000100034
COSMIC: PPM1F

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100034ENST00000263212P49593
ENSG00000100034ENST00000397495A8MX49
ENSG00000100034ENST00000407142B5MCT7
ENSG00000100034ENST00000424647C9JL74
ENSG00000100034ENST00000445205C9J2F3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221445832012MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.91
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118645732002The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.39
264986922015miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.22
200162862010The POPX2 phosphatase regulates cancer cell motility and invasiveness.13
243383622014POPX2 phosphatase regulates the KIF3 kinesin motor complex.10
216566822011Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis.9
294732402018Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer.9
304702612018CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.9
151408792004Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts.8

Citation

Dessen P

PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43425/ppm1f