PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

2003-05-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
BDP,MSUDMV,PP2Ckappa,PP2Cm,PTMP,UG0882E07
FUSION GENES

Other Information

Locus ID:

NCBI: 152926
MIM: 611065
HGNC: 25415
Ensembl: ENSG00000163644

Variants:

dbSNP: 152926
ClinVar: 152926
TCGA: ENSG00000163644
COSMIC: PPM1K

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163644ENST00000295908A0A0A0MQZ4
ENSG00000163644ENST00000505022V9GYS8
ENSG00000163644ENST00000508256V9GY69
ENSG00000163644ENST00000510548V9GYI6
ENSG00000163644ENST00000514204V9GYZ5
ENSG00000163644ENST00000608933Q8N3J5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Branched-chain amino acid catabolismREACTOMER-HSA-70895

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234468282013Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
189876182009Screening for replication of genome-wide SNP associations in sporadic ALS.14
173369292007Identification of a novel PP2C-type mitochondrial phosphatase.10
222910142012Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase.7
287686542017Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial.5
166854242006Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa.3
265925132015Regulation of PP2Cm expression by miRNA-204/211 and miRNA-22 in mouse and human cells.2
298558042018Association of branched chain amino acids related variant rs1440581 with risk of incident diabetes and longitudinal changes in insulin resistance in Chinese.1
304512842019Crystal structure and catalytic activity of the PPM1K N94K mutant.0

Citation

Dessen P

PPM1K (protein phosphatase, Mg2+/Mn2+ dependent 1K)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40324/ppm1k