PPP1CA (protein phosphatase 1 catalytic subunit alpha)

2003-06-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
PP-1A,PP1A,PP1alpha,PPP1A
FUSION GENES

Other Information

Locus ID:

NCBI: 5499
MIM: 176875
HGNC: 9281
Ensembl: ENSG00000172531

Variants:

dbSNP: 5499
ClinVar: 5499
TCGA: ENSG00000172531
COSMIC: PPP1CA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172531ENST00000312989P62136
ENSG00000172531ENST00000312989A0A140VJS9
ENSG00000172531ENST00000358239P62136
ENSG00000172531ENST00000376745P62136
ENSG00000172531ENST00000527663E9PMD7
ENSG00000172531ENST00000542876F5H037
ENSG00000172531ENST00000546202F5H1L6

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Long-term potentiationKEGGko04720
Regulation of actin cytoskeletonKEGGko04810
Insulin signaling pathwayKEGGko04910
Focal adhesionKEGGhsa04510
Long-term potentiationKEGGhsa04720
Regulation of actin cytoskeletonKEGGhsa04810
Insulin signaling pathwayKEGGhsa04910
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
DARPP-32 eventsREACTOMER-HSA-180024
Circadian ClockREACTOMER-HSA-400253
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33639PPP1R1BGenePathwayassociated

References

Pubmed IDYearTitleCitations
234994892013Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.118
184832222008PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.106
223605702013The PP1 binding code: a molecular-lego strategy that governs specificity.93
222845382013Structural basis for protein phosphatase 1 regulation and specificity.74
173181752007Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.55
189922562009Crystal structures of protein phosphatase-1 bound to nodularin-R and tautomycin: a novel scaffold for structure-based drug design of serine/threonine phosphatase inhibitors.43
211892572011PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.43
205160612010Identification and characterization of a novel human PP1 phosphatase complex.38
222996682013PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation.35
123938582002A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.33

Citation

Dessen P

PPP1CA (protein phosphatase 1 catalytic subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41804/ppp1ca