PPP1CC (protein phosphatase 1 catalytic subunit gamma)

2003-11-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
PP-1G,PP1C,PPP1G
FUSION GENES

Other Information

Locus ID:

NCBI: 5501
MIM: 176914
HGNC: 9283
Ensembl: ENSG00000186298

Variants:

dbSNP: 5501
ClinVar: 5501
TCGA: ENSG00000186298
COSMIC: PPP1CC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186298ENST00000335007P36873
ENSG00000186298ENST00000335007A0A024RBP2
ENSG00000186298ENST00000340766P36873
ENSG00000186298ENST00000546933F8W0W8
ENSG00000186298ENST00000550261F8W0V8
ENSG00000186298ENST00000550991F8VYE8
ENSG00000186298ENST00000551582F8W1A0
ENSG00000186298ENST00000551676F8VR82
ENSG00000186298ENST00000620030A0A087WYY5

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Long-term potentiationKEGGko04720
Regulation of actin cytoskeletonKEGGko04810
Insulin signaling pathwayKEGGko04910
Focal adhesionKEGGhsa04510
Long-term potentiationKEGGhsa04720
Regulation of actin cytoskeletonKEGGhsa04810
Insulin signaling pathwayKEGGhsa04910
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Circadian ClockREACTOMER-HSA-400253
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
234994892013Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.118
217231282011Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.45
179367022007S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.42
205160612010Identification and characterization of a novel human PP1 phosphatase complex.38
161314882005Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.31
122211032002Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.27
118567402002Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid.23
275722602016The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.20
162017492005Identification of a novel phosphatidic acid binding domain in protein phosphatase-1.15
163435322006Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins.12

Citation

Dessen P

PPP1CC (protein phosphatase 1 catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41806/ppp1cc