PPP1R10 (protein phosphatase 1 regulatory subunit 10)

2007-04-01  

Identity

HGNC
PPP1R10
LOCATION
6p21.33
LOCUSID
5514
ALIAS
CAT53,FB19,PNUTS,PP1R10,R111,p99
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5514
MIM: 603771
HGNC: 9284
Ensembl: ENSG00000204569

Variants:

dbSNP: 5514
ClinVar: 5514
TCGA: ENSG00000204569
COSMIC: PPP1R10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204569ENST00000376511Q96QC0
ENSG00000204569ENST00000376511Q2L6I0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
288256982017A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.64
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
245916422014Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.44
205160612010Identification and characterization of a novel human PP1 phosphatase complex.38
125741612003PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.28
208903102010The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.27
183601082008Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.22
173182202007Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.20
159071952005PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner.19
231178872013PNUTS functions as a proto-oncogene by sequestering PTEN.18

Citation

Dessen P

PPP1R10 (protein phosphatase 1 regulatory subunit 10)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47145/ppp1r10