PPP1R12A (protein phosphatase 1 regulatory subunit 12A)

2007-04-01  

Identity

HGNC
LOCATION
12q21.2
LOCUSID
ALIAS
GUBS,M130,MBS,MYPT1
FUSION GENES

Other Information

Locus ID:

NCBI: 4659
MIM: 602021
HGNC: 7618
Ensembl: ENSG00000058272

Variants:

dbSNP: 4659
ClinVar: 4659
TCGA: ENSG00000058272
COSMIC: PPP1R12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058272ENST00000261207O14974
ENSG00000058272ENST00000437004O14974
ENSG00000058272ENST00000450142O14974
ENSG00000058272ENST00000546369O14974
ENSG00000058272ENST00000546762H0YIS3
ENSG00000058272ENST00000547131H0YIS4
ENSG00000058272ENST00000547330F8VZN8
ENSG00000058272ENST00000548318F8VW28
ENSG00000058272ENST00000550107O14974
ENSG00000058272ENST00000550299H0YIM2
ENSG00000058272ENST00000550510H0YHL8
ENSG00000058272ENST00000550903H0YIL7
ENSG00000058272ENST00000553081H0YHI8
ENSG00000058272ENST00000634739A0A0U1RQZ1
ENSG00000058272ENST00000650220A0A3B3ISH4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Regulation of actin cytoskeletonKEGGko04810
Focal adhesionKEGGhsa04510
Regulation of actin cytoskeletonKEGGhsa04810
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
RHO GTPases activate PAKsREACTOMER-HSA-5627123
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184774602008Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.56
195314902009Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction.53
180791192008Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.50
157488952005Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly.28
119316302002Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton.26
226413462012LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression.26
206898072010Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.23
247123272014Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1.23
282418272017MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer.23

Citation

Dessen P

PPP1R12A (protein phosphatase 1 regulatory subunit 12A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47222/ppp1r12a