PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

2007-04-01  

Identity

HGNC
PPP1R15B
LOCATION
1q32.1
LOCUSID
84919
ALIAS
CREP,MSSGM2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84919
MIM: 613257
HGNC: 14951
Ensembl: ENSG00000158615

Variants:

dbSNP: 84919
ClinVar: 84919
TCGA: ENSG00000158615
COSMIC: PPP1R15B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158615ENST00000367188Q5SWA1

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
261591762015A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.16
229155832012A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.14
263070802015Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.10
253253772015CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.8
295991912018AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.6

Citation

Dessen P

PPP1R15B (protein phosphatase 1 regulatory subunit 15B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46951/ppp1r15b