PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)

2007-04-01  

Identity

HGNC
PPP1R2
LOCATION
3q29
LOCUSID
5504
ALIAS
IPP-2,IPP2,PPP1R2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5504
MIM: 601792
HGNC: 9288
Ensembl: ENSG00000184203

Variants:

dbSNP: 5504
ClinVar: 5504
TCGA: ENSG00000184203
COSMIC: PPP1R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184203ENST00000413183E7EUI7
ENSG00000184203ENST00000418939H7C416
ENSG00000184203ENST00000438848E7EMN6
ENSG00000184203ENST00000618156P41236
ENSG00000184203ENST00000625807E7EUI7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
332388882020The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.3
332388882020The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.3
235060012013Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.9
241957372013Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.7
235060012013Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.9
241957372013Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.7
217144982011Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.7
217144982011Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.7
187160572008Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.28
190361502008Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.12
187160572008Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.28
190361502008Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.12
166276252006Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.36
169875142006The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.13
166276252006Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.36

Citation

Dessen P

PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46630/ppp1r2