PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)

2007-04-01  

Identity

HGNC
PPP1R2
LOCATION
3q29
LOCUSID
5504
ALIAS
IPP-2,IPP2,PPP1R2A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5504
MIM: 601792
HGNC: 9288
Ensembl: ENSG00000184203

Variants:

dbSNP: 5504
ClinVar: 5504
TCGA: ENSG00000184203
COSMIC: PPP1R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184203ENST00000413183E7EUI7
ENSG00000184203ENST00000418939H7C416
ENSG00000184203ENST00000438848E7EMN6
ENSG00000184203ENST00000618156P41236
ENSG00000184203ENST00000625807E7EUI7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
166276252006Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.34
123938582002A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.33
122211032002Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.27
187160572008Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.23
169875142006The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.11
190361502008Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.11
235060012013Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.8
127611782003Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.7
217144982011Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.7
241957372013Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.7

Citation

Dessen P

PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46630/ppp1r2