PPP1R3A (protein phosphatase 1 regulatory subunit 3A)

2003-02-01  

Identity

HGNC
LOCATION
7q31.1
LOCUSID
ALIAS
GM,PP1G,PPP1R3

Other Information

Locus ID:

NCBI: 5506
MIM: 600917
HGNC: 9291
Ensembl: ENSG00000154415

Variants:

dbSNP: 5506
ClinVar: 5506
TCGA: ENSG00000154415
COSMIC: PPP1R3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154415ENST00000284601Q16821
ENSG00000154415ENST00000284602Q16821
ENSG00000154415ENST00000449795C9JZB3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121182512002Digenic inheritance of severe insulin resistance in a human pedigree.36
182327322008A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.16
121851562002Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.14
162763642006Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population.10
233593262013A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation.10
129417602003Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.7
195787962009Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.7
190564822009Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.5
117938472001The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus.4
117938472001The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus.4

Citation

Dessen P

PPP1R3A (protein phosphatase 1 regulatory subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41810/ppp1r3a