Identity
HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
GL,PPP1R4,PTG
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79660
MIM: 610541
HGNC: 14942
Ensembl: ENSG00000173281
Variants:
dbSNP: 79660
ClinVar: 79660
TCGA: ENSG00000173281
COSMIC: PPP1R3B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000173281 | ENST00000310455 | Q86XI6 |
| ENSG00000173281 | ENST00000519699 | Q86XI6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Insulin signaling pathway | KEGG | ko04910 |
| Insulin signaling pathway | KEGG | hsa04910 |
| Insulin resistance | KEGG | hsa04931 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33231259 | 2021 | A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction. | 9 |
| 33553972 | 2021 | Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. | 5 |
| 33231259 | 2021 | A Noncoding Variant Near PPP1R3B Promotes Liver Glycogen Storage and MetS, but Protects Against Myocardial Infarction. | 9 |
| 33553972 | 2021 | Protein Phosphatase 1 Regulatory Subunit 3B Genotype at rs4240624 Has a Major Effect on Gallbladder Bile Composition. | 5 |
| 32219298 | 2020 | Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose. | 3 |
| 32219298 | 2020 | Genetic Variation at PPP1R3B Increases Hepatic CT Attenuation and Interacts With Prandial Status on Plasma Glucose. | 3 |
| 30629617 | 2019 | Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes. | 6 |
| 30629617 | 2019 | Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes. | 6 |
| 29266543 | 2018 | Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. | 32 |
| 29266543 | 2018 | Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. | 32 |
| 26433129 | 2016 | GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. | 8 |
| 27752939 | 2016 | Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. | 13 |
| 26433129 | 2016 | GCKR and PPP1R3B identified as genome-wide significant loci for plasma lactate: the Atherosclerosis Risk in Communities (ARIC) study. | 8 |
| 27752939 | 2016 | Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. | 13 |
| 26182369 | 2015 | Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death. | 4 |
Citation
Dessen P
PPP1R3B (protein phosphatase 1 regulatory subunit 3B)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46909/ppp1r3b
