PPP1R3C (protein phosphatase 1 regulatory subunit 3C)

2007-04-01  

Identity

HGNC
LOCATION
10q23.32
LOCUSID
ALIAS
PPP1R5,PTG

Other Information

Locus ID:

NCBI: 5507
MIM: 602999
HGNC: 9293
Ensembl: ENSG00000119938

Variants:

dbSNP: 5507
ClinVar: 5507
TCGA: ENSG00000119938
COSMIC: PPP1R3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119938ENST00000238994Q9UQK1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
DiseaseREACTOMER-HSA-1643685
Diseases of metabolismREACTOMER-HSA-5668914
Diseases of carbohydrate metabolismREACTOMER-HSA-5663084
Glycogen storage diseasesREACTOMER-HSA-3229121
Myoclonic epilepsy of LaforaREACTOMER-HSA-3785653
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
Glycogen synthesisREACTOMER-HSA-3322077
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375112122023AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous Ovarian Cancer.2
375112122023AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous Ovarian Cancer.2
329156482022MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by Targeting PPP1R3C.8
329156482022MiR-4461 Inhibits Tumorigenesis of Renal Cell Carcinoma by Targeting PPP1R3C.8
258468792015The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.11
258468792015The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer.11
248614852014Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.24
248614852014Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients.24
217386312011A PTG variant contributes to a milder phenotype in Lafora disease.12
217386312011A PTG variant contributes to a milder phenotype in Lafora disease.12
208888142010Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia.45
208888142010Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia.45
191719322009AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.31
191719322009AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex.31
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83

Citation

Dessen P

PPP1R3C (protein phosphatase 1 regulatory subunit 3C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46712/ppp1r3c