PPP1R7 (protein phosphatase 1 regulatory subunit 7)

2007-04-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
SDS22
FUSION GENES

Other Information

Locus ID:

NCBI: 5510
MIM: 602877
HGNC: 9295
Ensembl: ENSG00000115685

Variants:

dbSNP: 5510
ClinVar: 5510
TCGA: ENSG00000115685
COSMIC: PPP1R7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115685ENST00000234038Q15435
ENSG00000115685ENST00000234038A0A140VK83
ENSG00000115685ENST00000272983Q15435
ENSG00000115685ENST00000401987Q15435
ENSG00000115685ENST00000402734Q15435
ENSG00000115685ENST00000404405B5MBZ8
ENSG00000115685ENST00000406106Q15435
ENSG00000115685ENST00000407025Q15435
ENSG00000115685ENST00000407025A0A140VK83
ENSG00000115685ENST00000415769H7C3Q5
ENSG00000115685ENST00000423280C9J177
ENSG00000115685ENST00000427172H7C118
ENSG00000115685ENST00000438799C9JD73
ENSG00000115685ENST00000439916C9JRC4
ENSG00000115685ENST00000450367H7C003

Expression (GTEx)

0
50
100
150
200
250

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209211352010Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis.54
261683972015Kinetochore-localized PP1-Sds22 couples chromosome segregation to polar relaxation.35
228017822012Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.34
176307782007A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.22
213996592011Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.14
252983952014Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.14
276856282016The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells.7
275576602016Phosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation.4
296697862018Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.3
305006802019Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway.3

Citation

Dessen P

PPP1R7 (protein phosphatase 1 regulatory subunit 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47131/ppp1r7