PPP2R3C (protein phosphatase 2 regulatory subunit Bgamma)

2014-11-01  

Identity

HGNC
LOCATION
14q13.2
LOCUSID
ALIAS
C14orf10,G4-1,G5pr,GDRM,SPGF36
FUSION GENES

Other Information

Locus ID:

NCBI: 55012
MIM: 615902
HGNC: 17485
Ensembl: ENSG00000092020

Variants:

dbSNP: 55012
ClinVar: 55012
TCGA: ENSG00000092020
COSMIC: PPP2R3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092020ENST00000261475Q969Q6
ENSG00000092020ENST00000553273G3V228
ENSG00000092020ENST00000553282G3V3T9
ENSG00000092020ENST00000554222G3V228
ENSG00000092020ENST00000554265G3V228
ENSG00000092020ENST00000554361G3V2K1
ENSG00000092020ENST00000554488G3V228
ENSG00000092020ENST00000554563G3V5U8
ENSG00000092020ENST00000554899G3V228
ENSG00000092020ENST00000555219H0YJV0
ENSG00000092020ENST00000555614H0YJC5
ENSG00000092020ENST00000555630G3V561
ENSG00000092020ENST00000555644Q86US5
ENSG00000092020ENST00000555726H0YJR2
ENSG00000092020ENST00000557074H0YJ16
ENSG00000092020ENST00000557217G3V228
ENSG00000092020ENST00000557278A0A0C4DGK2
ENSG00000092020ENST00000557288G3V3V5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243337282014Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.9
227539442012Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice.2
308936442019PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans.2

Citation

Dessen P

PPP2R3C (protein phosphatase 2 regulatory subunit Bgamma)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72154/ppp2r3c