Identity
HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
B56E,B56epsilon
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5529
MIM: 601647
HGNC: 9313
Ensembl: ENSG00000154001
Variants:
dbSNP: 5529
ClinVar: 5529
TCGA: ENSG00000154001
COSMIC: PPP2R5E
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000154001 | ENST00000337537 | Q16537 |
| ENSG00000154001 | ENST00000422769 | Q16537 |
| ENSG00000154001 | ENST00000555899 | Q16537 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443635 | Cardiovascular Diseases | Disease | VariantAnnotation | not associated | PD | 24816038 | |
| PA446021 | Vascular Diseases | Disease | VariantAnnotation | not associated | PD | 24816038 | |
| PA451089 | pravastatin | Chemical | VariantAnnotation | not associated | PD | 24816038 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37175484 | 2023 | Deregulation of the miR-19b/PPP2R5E Signaling Axis Shows High Functional Impact in Colorectal Cancer Cells. | 2 |
| 37175484 | 2023 | Deregulation of the miR-19b/PPP2R5E Signaling Axis Shows High Functional Impact in Colorectal Cancer Cells. | 2 |
| 32847850 | 2020 | Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. | 6 |
| 32847850 | 2020 | Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. | 6 |
| 30352868 | 2019 | Mapping of breakpoints in balanced chromosomal translocations by shallow whole-genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders. | 10 |
| 30352868 | 2019 | Mapping of breakpoints in balanced chromosomal translocations by shallow whole-genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders. | 10 |
| 27521566 | 2016 | A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1. | 4 |
| 27521566 | 2016 | A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1. | 4 |
| 25772433 | 2015 | PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks. | 15 |
| 25772433 | 2015 | PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks. | 15 |
| 24997345 | 2014 | Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells. | 19 |
| 25512391 | 2014 | KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle. | 44 |
| 24997345 | 2014 | Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells. | 19 |
| 25512391 | 2014 | KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle. | 44 |
| 23812941 | 2013 | Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells. | 14 |
Citation
Dessen P
PPP2R5E (protein phosphatase 2 regulatory subunit Bepsilon)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41821/ppp2r5e
