PPP4R3A (protein phosphatase 4 regulatory subunit 3A)

2016-09-01  

Identity

HGNC
PPP4R3A
LOCATION
14q32.12
LOCUSID
55671
ALIAS
FLFL1,KIAA2010,MSTP033,PP4R3,PP4R3A,SMEK1,smk-1,smk1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55671
MIM: 610351
HGNC: 20219
Ensembl: ENSG00000100796

Variants:

dbSNP: 55671
ClinVar: 55671
TCGA: ENSG00000100796
COSMIC: PPP4R3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100796ENST00000554308H0YIY8
ENSG00000100796ENST00000554390G3V5Z3
ENSG00000100796ENST00000554511G3V4R3
ENSG00000100796ENST00000554684Q6IN85
ENSG00000100796ENST00000554684A0A024R6M2
ENSG00000100796ENST00000554943Q6IN85
ENSG00000100796ENST00000555029G3V5A2
ENSG00000100796ENST00000555462Q6IN85
ENSG00000100796ENST00000555470H0YJN6
ENSG00000100796ENST00000557018G3V231

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
263788102015sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways.8
223492392012Tumor suppressor BLU enhances pro-apoptotic activity of sMEK1 through physical interaction.3
278782922017BMI-1 interacts with sMEK1 and inactivates sMEK1-induced apoptotic cell death.1
291305212017A variant in PPP4R3A protects against alzheimer-related metabolic decline.1

Citation

Dessen P

PPP4R3A (protein phosphatase 4 regulatory subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2016-09-01

Online version: http://atlasgeneticsoncology.org/gene/55942/ppp4r3a