PPP6C (protein phosphatase 6 catalytic subunit)

2003-11-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
PP6,PP6C
FUSION GENES

Other Information

Locus ID:

NCBI: 5537
MIM: 612725
HGNC: 9323
Ensembl: ENSG00000119414

Variants:

dbSNP: 5537
ClinVar: 5537
TCGA: ENSG00000119414
COSMIC: PPP6C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119414ENST00000373547O00743
ENSG00000119414ENST00000373547A0A024R861
ENSG00000119414ENST00000415905O00743
ENSG00000119414ENST00000451402O00743
ENSG00000119414ENST00000456642Q5T1S7

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211873292010Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.78
200650382010Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.68
167697272006Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.45
261383682015NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.45
191986482009Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.34
237297332013Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A.27
251875372014Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication.24
214811882011MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma.23
175681942007Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.22
264627362015Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.21

Citation

Dessen P

PPP6C (protein phosphatase 6 catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41826/ppp6c